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Прошла первые испытания вакцина против рака молочной железы

Опубликовано : 17-12-2014, 16:11 | Опубликовал: Анастасия Мотлох | Категория: Диагностика

Сотрудники медицинского факультета университета Вашингтона в Сент-Луисе провели клинические испытания вакцины, которая должна будет помочь женщинам в борьбе с раком молочной железы. В состав новой вакцины входят молекулы ДНК содержащие ген, кодирующий маммаглобин-А – белок, который при раке груди начинает воспроизводиться в огромных количествах. После проведенной вакцинации в 80% клетки, вырабатывающие маммаглобин-А, ликвидируются. 

Занималась исследованием безопасности вакцины команда врачей под руководством д-ра Уильяма Джилландерса, доктора медицинских наук, профессора хирургии, специализирующегося на опухолях груди. Вакцинирование было проведено 14 пациенткам с метастатическим раком груди. В течение года после вакцинации у 12 пациенток состояние стабилизировалось и перестало ухудшаться, в то время как у контрольной группы, которая проходила лечение обычными методами состояние улучшилось только у двоих женщин. Вакцинация прошла практически без осложнений - у 8 пациенток наблюдались легкие недомогания похожие на грипп. Авторы исследования сделали вывод, что вакцина замедляет развитие заболевания даже на поздних стадиях уже после проведенного лечения химиотерапией. Несмотря на небольшие цифры эта статистика является значимой при проведении исследований. 

Далее учеными планируется изучение воздействия вакцины на больных с более легкими стадиями рака, у которых еще сохраняется иммунитет. Есть предположение, что в этом случае эффект от вакцинации будет более сильным. На первой стадии исследования вакцины ученые убедились в её полной безопасности для пациенток.  

Главным маркером рака груди является белок маммаглобин-А (МАМ). Если диагностируется резкое возрастание белка, то это свидетельствует о развитии опухоли в тканях. Вакцина активизирует лейкоциты, которые действуют на молекулы белка МАМ и они нейтрализуются. Онкологическое образование на долгое время прекращает свое развитие. Есть еще часть больных, у которых опухоли не производят маммаглобин-А, в этих случаях вакцина будет неэффективной. 

Первоисточник - http://news.wustl.edu/news/Pages/27732.aspx

This work was supported by the Breast Cancer Research Program (BCRP) of the Department of Defense Congressionally Directed Medical Research Programs (DOD/CDMRP), grant number W81XWH-61-0677; Gateway for Cancer Research, P-06-016; The Foundation for Barnes-Jewish Hospital; the National Cancer Institute (NCI) of the National Institutes of Health (NIH), T32 CA009621; the NCI Cancer Center Support Grant, P30 CA91842; and George and Diana Holway.

Tiriveedhi V, Tucker N, Herndon J, Li L, Sturmoski M, Ellis M, Ma C, Naughton M, Lockhart AC, Gao F, Fleming T, Goedegebuure P, Mohanakumar T, Gillanders WE. Safety and preliminary evidence of biological efficacy of a mammaglobin-A DNA vaccine in patients with stable metastatic breast cancer. Clinical Cancer Research. Dec. 1, 2014.

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